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KMID : 0100120050010010091
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Korean Journal of Korean Medical Institute of Dermatology and Aesthetics
2005 Volume.1 No. 1 p.91 ~ p.97
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Inhibitory Activity of Medicinal Plant Extracts against Tyrosinase
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Na Min-Kyun
Choi Seung-Youl
Kim Dong-Hee
Kim Jin-Pyo
Lee Chan-Bok
Kim Kyung-Dong
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Abstract
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(1) Objectives: To discover natural skin-lightening agents, we have evaluated the inhibitory activity of EtOH extracts from 20 medicinal plants against mushroom tyrosinase.
(2) Methods: Tyrosinase activity was determined by the dopachrome method using L-tyrosine as the substrates.
(3) Results: Of the plant extracts tested, the extracts of 4 plants, Albizzia julibrissin, Curcuma longa, Anethum graveolens and Sophora flavescens, exhibited potent inhibitory activity (> 50%) in mushroom tyrosinase assay. Four plant extract, extracts of Agrimonia pilosa, Paeonia moutan, Magnolia obovata and Eugenia caryophyllata also showed relatively strong inhibitory (> 40%) against mushroom tyrosinase.
(4) Conclusion: These active medicinal plants may be useful for the development of skin-whitening agents. Since the active medicinal plants may contain effective tyrosinase inhibitors even more than kojic acid, further study to identify the active constituents from the plants is expected.
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